Ipamorelin
Growth Hormone Secretagogue · Sleep · Body Composition
View Product & Pricing →What Is Ipamorelin?
Ipamorelin is a pentapeptide growth hormone releasing peptide (GHRP) that selectively stimulates the pituitary gland to release growth hormone. Unlike earlier GHRPs, Ipamorelin is noted for its high selectivity — it does not significantly increase cortisol, prolactin, or other stress-related hormones at research doses.
Research into Ipamorelin has explored its potential role in improving GH pulse amplitude, enhancing sleep quality, and supporting lean body composition. Its selectivity and tolerability profile have made it a frequently studied compound in the growth hormone secretagogue class.
How It Works
Ipamorelin binds to the ghrelin receptor (GHS-R1a) in the pituitary gland, stimulating a pulse of growth hormone release without activating ACTH or cortisol pathways. This selective action distinguishes it from non-selective GHRPs and makes it a cleaner tool for studying GH physiology.
Key Research Findings
Growth Hormone Release
Studies demonstrate Ipamorelin reliably increases GH pulse amplitude in a dose-dependent manner, without desensitising the pituitary over repeated exposures at research doses.
Sleep Architecture
Growth hormone is primarily secreted during slow-wave sleep. Research suggests Ipamorelin-induced GH release may support deeper sleep stages, with associated downstream effects on recovery and tissue repair.
Body Composition
Animal and early human studies have examined Ipamorelin's influence on lean mass retention and fat metabolism, consistent with known downstream effects of GH signalling on IGF-1 production.
Selectivity Profile
A key distinction in the literature is Ipamorelin's lack of significant cortisol or prolactin elevation at effective research doses — a property that differentiates it from earlier-generation GHRPs such as GHRP-2 and GHRP-6.
Research-Grade Ipamorelin
Pharmaceutical-grade formulation. Order via WhatsApp or Telegram.
For research purposes only. This page does not constitute medical advice. Consult a qualified healthcare professional before use. Clinician review required where mandated by law.